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Zarządzanie rozbudową fabryki farmaceutycznej ; Zarządzanie rozbudową fabryki farmaceutycznej ;

Pharmaceutical production plant extension, Poland

Managing the expansion of an innovative pharma factory and lab

Disruptive advances in biotechnology paired with cost-effective manufacturing and supply-chain management make speed-to-market a key success metric for many pharmaceutical companies nowadays. To meet fast-growing market demand, a leading Eastern Europe pharma group was keen to optimise operations at one of its plants in Poland.

The expansion of the existing plant, specialised in soft gelatine capsules as well as liquid medications like suspensions and syrups, would effectively double its production capacity. A new building within the facility would enable the company to tap into innovative inhalants for lung treatment.

The pharmaceutical group appointed Arup to manage the project and costs, as well as supervise the expansion of the plant, which includes a lab and two innovative, automated production lines. The brief was to create a more effective, scalable production process and manufacturing environment.

Project Summary

10,000m2 area

2 automated production lines

Pharma: multi-disciplinary know-how

Although it might look like a standard production plant from the outside, the building reveals a web of complex, mostly automated systems inside. The production plant features an advanced Building Management Systems (BMS), a nervous system to regulate the overall operations of the facility including essential systems such as ventilation, heating and cooling.

Crucially for the facility, the BMS monitors internal environmental parameters including humidity, temperature and pressure, as well as automated gates, energy and security systems. The production plant includes a range of other required installations: a clean steam system, which ensures appropriate air humidity levels in cleanrooms; a technical steam system used for heating products; clean gas installations distributing nitrogen and helium; vacuum and compressed air systems as well as a condensation system to gather condensate and enable valuable purified water to be re-used several times.

To implement these inter-dependent automated systems, we drew our team of in-house experts from across all disciplines– from HVAC and clean media systems to electrical engineering and automation.

Sourcing specialists from different providers poses a risk of dispersed responsibility, which could negatively impact the scheduled delivery. Arup’s integrated, multidisciplinary approach helped facilitate and accelerate the project delivery while ensuring regulatory compliance including URS (User Requirement Specification).

Project managing a complex extension

Planning the enlargement of a pharma plant is a complex task requiring careful management: many elements need to come together at exactly the right time.

Our previous experience with the client held us in good stead: we had worked as technical consultant, quality and site works supervisor covering HVAC, mechanical and electrical systems during the modernisation of another production plant in central Asia.

Translating client requirements into optimal processes, we took into account many aspects such as integrating contractor capabilities and advised on the best ways of employing existing installations and equipment.

Project managers need to be fully aware of the network of dependencies between all the installations to plan the execution and validation processes adequately. Our in-house know-how in the planning and managing a construction project ensured the smooth completion of this crucial pharma plant extension.

All installations were delivered to the highest standard to avoid additional disruptive upgrade works once the factory was on production mode.

In terms of budget, the combined experience of our engineers and project managers and our strong read of the contractor market allowed for efficient cost-management to offer an accurate assessment of the total value of the plant’s extension work.

Managing the extension of this complex pharma production plant required constant collaboration and commitment, to ensure that this project was delivered to schedule and within budget. ” Marcin Giers Arup Marcin Giers Associate

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